Flying Solo

Flying solo: chemotherapy without radiation for primary CNS lymphoma.

Primary CNS lymphoma (PCNSL) is an uncommon type of extranodal non-Hodgkin lymphoma confined to the brain, leptomeninges, or eyes. Although more than 90% of PCNSL tumors are classified histologically as diffuse large B-cell lymphoma, the survival of patients with PCNSL remains inferior to that observed in patients with diffuse large B-cell lymphoma occurring in other body sites. This may result...

Solo polarization

eterochromatin’s repressive hold on DNA transcription can only be relinquished when activators enter the nucleus. Or so the theory goes. But now Vanessa Witte, Andreas Baur (University of Erlangen, Germany), and colleagues find that a heterochromatin component can be pulled from the nucleus by both the HIV protein Nef and activated integrins. “This is a really new concept—that chromatin-associa...

Solo Diagrams

We address the problems of implementing the replication operator efficiently in the solos calculus—a calculus of mobile processes without prefix. This calculus is expressive enough to admit an encoding of the whole fusion calculus and thus the π-calculus. We show that nested occurrences of replication can be avoided, that the size of replicated terms can be limited to three particles, and that ...

SOLO: A Cognitive Orthosis

Solo is a cognitive assistive device which provides support in remembering when to perform tasks, executing the steps in a task, and recovering from unexpected events. The system includes an interface for clients to receive reminders, an interface for caregivers to enter information about the client’s scheduled tasks, and a Cognition Manager which provides reminders and task guidance at appropr...

The solo/duo gap